Pub. Date : 2010 Oct
PMID : 20739403
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DHT selectively reverses Smad3-mediated/TGF-beta-induced responses through transcriptional down-regulation of Smad3 in prostate epithelial cells. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 2 | We have recently reported that 5alpha-dihydrotestosterone (DHT) suppresses the ability of TGF-beta to inhibit proliferation and induce apoptosis of prostatic epithelial cells and provided evidence that such suppression was fueled by transcriptional down-regulation of TGF-beta receptor II (TaubetaRII). | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 3 | We have recently reported that 5alpha-dihydrotestosterone (DHT) suppresses the ability of TGF-beta to inhibit proliferation and induce apoptosis of prostatic epithelial cells and provided evidence that such suppression was fueled by transcriptional down-regulation of TGF-beta receptor II (TaubetaRII). | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 4 | We have recently reported that 5alpha-dihydrotestosterone (DHT) suppresses the ability of TGF-beta to inhibit proliferation and induce apoptosis of prostatic epithelial cells and provided evidence that such suppression was fueled by transcriptional down-regulation of TGF-beta receptor II (TaubetaRII). | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 5 | We have recently reported that 5alpha-dihydrotestosterone (DHT) suppresses the ability of TGF-beta to inhibit proliferation and induce apoptosis of prostatic epithelial cells and provided evidence that such suppression was fueled by transcriptional down-regulation of TGF-beta receptor II (TaubetaRII). | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 6 | We now show that androgen receptor (AR) activated by DHT suppresses the TGF-beta-induced phosphorylation of Sma- and Mad-related protein (Smad)3 in LNCaP cells overexpressing TbetaRII under the control of a cytomegalovirus promoter, which is not regulated by DHT, suggesting that transcriptional repression of TbetaRII alone does not fully account for the impact of DHT on TGF-beta responses. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 7 | We now show that androgen receptor (AR) activated by DHT suppresses the TGF-beta-induced phosphorylation of Sma- and Mad-related protein (Smad)3 in LNCaP cells overexpressing TbetaRII under the control of a cytomegalovirus promoter, which is not regulated by DHT, suggesting that transcriptional repression of TbetaRII alone does not fully account for the impact of DHT on TGF-beta responses. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 8 | We now show that androgen receptor (AR) activated by DHT suppresses the TGF-beta-induced phosphorylation of Sma- and Mad-related protein (Smad)3 in LNCaP cells overexpressing TbetaRII under the control of a cytomegalovirus promoter, which is not regulated by DHT, suggesting that transcriptional repression of TbetaRII alone does not fully account for the impact of DHT on TGF-beta responses. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 9 | We now show that androgen receptor (AR) activated by DHT suppresses the TGF-beta-induced phosphorylation of Sma- and Mad-related protein (Smad)3 in LNCaP cells overexpressing TbetaRII under the control of a cytomegalovirus promoter, which is not regulated by DHT, suggesting that transcriptional repression of TbetaRII alone does not fully account for the impact of DHT on TGF-beta responses. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 10 | Moreover, we show that overexpression of Smad3 reverses the ability of DHT to protect against TGF-beta-induced apoptosis in NRP-154+AR, supporting our model that loss of Smad3 by DHT is involved in the protection against TGF-beta-induced apoptosis. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 11 | Moreover, we show that overexpression of Smad3 reverses the ability of DHT to protect against TGF-beta-induced apoptosis in NRP-154+AR, supporting our model that loss of Smad3 by DHT is involved in the protection against TGF-beta-induced apoptosis. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 12 | Moreover, we show that overexpression of Smad3 reverses the ability of DHT to protect against TGF-beta-induced apoptosis in NRP-154+AR, supporting our model that loss of Smad3 by DHT is involved in the protection against TGF-beta-induced apoptosis. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |