Title : Cytoprotective effects of acidosis via heat shock protein HSP27 against the anticancer drug doxorubicin.

Pub. Date : 2011 Mar

PMID : 20730553






2 Functional Relationships(s)
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1 Low pH culture conditions were found to dramatically prolong cell survival after doxorubicin treatment, an effect that was in part reversed by co-incubation with the specific p38 mitoge-activated protein kinase (MAP kinase) inhibitor SB203580, only mildly inhibited by blockade of the multi-drug resistance 1 (MDR1) transporter, but completely abolished by siRNA-mediated knockdown of the heat shock protein 27 (HSP27). SB 203580 heat shock protein family B (small) member 1 Homo sapiens
2 Low pH culture conditions were found to dramatically prolong cell survival after doxorubicin treatment, an effect that was in part reversed by co-incubation with the specific p38 mitoge-activated protein kinase (MAP kinase) inhibitor SB203580, only mildly inhibited by blockade of the multi-drug resistance 1 (MDR1) transporter, but completely abolished by siRNA-mediated knockdown of the heat shock protein 27 (HSP27). SB 203580 heat shock protein family B (small) member 1 Homo sapiens