Pub. Date : 2010 Aug 20
PMID : 20727180
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. | Nicotine | tumor protein p53 | Homo sapiens |
| 2 | We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. | Nicotine | tumor protein p53 | Homo sapiens |
| 3 | We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. | Nicotine | tumor protein p53 | Homo sapiens |
| 4 | We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. | Nicotine | tumor protein p53 | Homo sapiens |
| 5 | We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. | Nicotine | tumor protein p53 | Homo sapiens |
| 6 | We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. | Nicotine | tumor protein p53 | Homo sapiens |
| 7 | We observed that the proliferative index of nicotine is different in the lung cancer cell lines H1299 (p53-/-) and A549 (p53+/+) which indicates that the mode of up-regulation of survival signals by nicotine might be different in cells with and without p53. | Nicotine | tumor protein p53 | Homo sapiens |
| 8 | The hypothesis was confirmed when lower concentrations of nicotine induced NF-kappaB in two more lung cancer cells, Hop-92 and NCI-H522 with mutant p53 status. | Nicotine | tumor protein p53 | Homo sapiens |
| 9 | Silencing of p53 in A549 using siRNA made the cells susceptible to nicotine-induced NF-kappaB nuclear translocation as in A549 DN-p53 cells. | Nicotine | tumor protein p53 | Homo sapiens |
| 10 | Silencing of p53 in A549 using siRNA made the cells susceptible to nicotine-induced NF-kappaB nuclear translocation as in A549 DN-p53 cells. | Nicotine | tumor protein p53 | Homo sapiens |
| 11 | CONCLUSIONS: The present study reveals a detrimental role of nicotine especially in lung cancer patients with impaired p53 status and identifies curcumin as a potential chemopreventive. | Nicotine | tumor protein p53 | Homo sapiens |