Title : Molecular alterations associated with sulindac-resistant colon tumors in ApcMin/+ mice.

Pub. Date : 2010 Sep

PMID : 20716632






2 Functional Relationships(s)
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1 Sulindac is also known to exert its growth inhibitory effects through regulation of many noncyclooxygenase targets, including p21, beta-catenin, E-cadherin, mitochondrial apoptotic proteins, and peroxisome proliferator-activated receptor-gamma. Sulindac catenin (cadherin associated protein), beta 1 Mus musculus
2 We found that sulindac treatment protected against E-cadherin loss in colon tumors, with associated inhibition of nuclear beta-catenin accumulation. Sulindac catenin (cadherin associated protein), beta 1 Mus musculus