Title : Metabolism of 1'- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7.

Pub. Date : 2010 Nov

PMID : 20713656






2 Functional Relationships(s)
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1 A correlation analysis of UGT enzymatic activity and the formation rate of glucuronide metabolites from 1"- and 4-hydroxymidazolam in 25 HLMs showed that hydroxymidazolam glucuronidation is correlated with UGT1A4-mediated lamotrigine glucuronidation and UGT2B7-mediated diclofenac glucuronidation activity. Glucuronides UDP glucuronosyltransferase family 1 member A4 Homo sapiens
2 Taken together, these findings indicate that UGT1A4, 2B4, and 2B7 are major isoforms responsible for glucuronide conjugate formation from 1"- and 4-hydroxymidazolam, which are the two major oxidative metabolites of midazolam. Glucuronides UDP glucuronosyltransferase family 1 member A4 Homo sapiens