Title : microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease.

Pub. Date : 2010 Nov 18

PMID : 20709907






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1 We further demonstrate that increased miR-144 is associated with reduced NRF2 levels in HbSS reticulocytes and with decreased glutathione regeneration and attenuated antioxidant capacity in HbSS erythrocytes, thereby providing a possible mechanism for the reduced oxidative stress tolerance and increased anemia severity seen in HbSS patients. hbss microRNA 144 Homo sapiens