Pub. Date : 2010 Oct
PMID : 20709787
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously described a genetically engineered C. albicans tet-NRG1 strain in which NRG1 expression levels can be manipulated by the presence or absence of doxycycline (DOX). | tetramethylenedisulfotetramine | transcriptional regulator NRG1 | Saccharomyces cerevisiae S288C |
| 2 | We have previously described a genetically engineered C. albicans tet-NRG1 strain in which NRG1 expression levels can be manipulated by the presence or absence of doxycycline (DOX). | tetramethylenedisulfotetramine | transcriptional regulator NRG1 | Saccharomyces cerevisiae S288C |
| 3 | In an in vitro model of biofilm formation, the C. albicans tet-NRG1 strain was able to form mature biofilms only when DOX was present in the medium, but not in the absence of DOX, when high levels of NRG1 expression blocked the yeast-to-hypha transition. | tetramethylenedisulfotetramine | transcriptional regulator NRG1 | Saccharomyces cerevisiae S288C |
| 4 | In an in vitro model of biofilm formation, the C. albicans tet-NRG1 strain was able to form mature biofilms only when DOX was present in the medium, but not in the absence of DOX, when high levels of NRG1 expression blocked the yeast-to-hypha transition. | tetramethylenedisulfotetramine | transcriptional regulator NRG1 | Saccharomyces cerevisiae S288C |
| 5 | However, in a biofilm cell retention assay in which biofilms were developed with mixtures of C. albicans tet-NRG1 and SC5314 strains, tet-NRG1 yeast cells were still incorporated into the mixed biofilms, in which an intricate network of hyphae of the wild-type strain provided for biofilm structural integrity and adhesive interactions. | tetramethylenedisulfotetramine | transcriptional regulator NRG1 | Saccharomyces cerevisiae S288C |