Pub. Date : 2010 Oct 29
PMID : 20709133
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chlorpyrifos metabolism by individual human liver microsomes was significantly correlated with CYP2B6, CYP2C19 and CYP3A4 related activity. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | CPO formation was best correlated with CYP2B6 related activity at low (20 muM) chlorpyrifos concentrations while CYP3A4 related activity was best correlated with CPO formation at high concentrations (100 muM) of chlorpyrifos. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Calculations of percent total normalized rates (% TNR) and the chemical inhibitors ketoconazole and ticlopidine were used to confirm the importance of CYP2B6, CYP2C19, and CYP3A4 for the metabolism of chlorpyrifos. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |