Title : The effect of class II transactivator mutations on bleomycin-induced lung inflammation and fibrosis.

Pub. Date : 2011 Jun

PMID : 20705943






3 Functional Relationships(s)
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1 IFN-gamma expression increases during the inflammatory response after bleomycin injury in mice. Bleomycin interferon gamma Mus musculus
2 Because IFN-gamma stimulates class II transactivator (CIITA) expression, which activates major histocompatibility class (MHC) II and represses collagen expression, it was hypothesized that CIITA mediates IFN-gamma action after bleomycin injury. Bleomycin interferon gamma Mus musculus
3 Because IFN-gamma stimulates class II transactivator (CIITA) expression, which activates major histocompatibility class (MHC) II and represses collagen expression, it was hypothesized that CIITA mediates IFN-gamma action after bleomycin injury. Bleomycin interferon gamma Mus musculus