Title : The simultaneous determination of NAD(H) and NADP(H) utilization by glutamate dehydrogenase.

Pub. Date : 2010 Nov

PMID : 20697932






8 Functional Relationships(s)
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1 The simultaneous determination of NAD(H) and NADP(H) utilization by glutamate dehydrogenase. NAD glutamate dehydrogenase 1 Homo sapiens
2 Glutamate dehydrogenase (GDH) from vertebrates is unusual among NAD(P)H-dependent dehydrogenases in that it can use either NAD(H) or NADP(H) as cofactor. NAD glutamate dehydrogenase 1 Homo sapiens
3 Glutamate dehydrogenase (GDH) from vertebrates is unusual among NAD(P)H-dependent dehydrogenases in that it can use either NAD(H) or NADP(H) as cofactor. NAD glutamate dehydrogenase 1 Homo sapiens
4 Methods for both reaction directions were developed, and for the first time, to our knowledge, the GDH activity has been simultaneously studied in the presence of both NAD(H) and NADP(H). NAD glutamate dehydrogenase 1 Homo sapiens
5 Our data indicate that NADP(H) has inhibitory effects on the rate of NAD(H) utilization by GDH, a characteristic of GDH not previously recognized. NAD glutamate dehydrogenase 1 Homo sapiens
6 Our data indicate that NADP(H) has inhibitory effects on the rate of NAD(H) utilization by GDH, a characteristic of GDH not previously recognized. NAD glutamate dehydrogenase 1 Homo sapiens
7 The response of GDH to allosteric activators in the presence of NAD(H) and NADP(H) suggests that ADP and leucine moderate much of the inhibitory effect of NADP(H) on the utilization of NAD(H). NAD glutamate dehydrogenase 1 Homo sapiens
8 The response of GDH to allosteric activators in the presence of NAD(H) and NADP(H) suggests that ADP and leucine moderate much of the inhibitory effect of NADP(H) on the utilization of NAD(H). NAD glutamate dehydrogenase 1 Homo sapiens