Title : Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling.

Pub. Date : 2010 Nov

PMID : 20693278






5 Functional Relationships(s)
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1 When treated with paclitaxel or vinorelbine, breast cancer cells with constitutive activation of STAT3 display a loss of STAT3 phosphorylation, and paclitaxel disrupts the interaction of STAT3 with tubulin. Paclitaxel signal transducer and activator of transcription 3 Homo sapiens
2 When treated with paclitaxel or vinorelbine, breast cancer cells with constitutive activation of STAT3 display a loss of STAT3 phosphorylation, and paclitaxel disrupts the interaction of STAT3 with tubulin. Paclitaxel signal transducer and activator of transcription 3 Homo sapiens
3 When treated with paclitaxel or vinorelbine, breast cancer cells with constitutive activation of STAT3 display a loss of STAT3 phosphorylation, and paclitaxel disrupts the interaction of STAT3 with tubulin. Paclitaxel signal transducer and activator of transcription 3 Homo sapiens
4 When treated with paclitaxel or vinorelbine, breast cancer cells with constitutive activation of STAT3 display a loss of STAT3 phosphorylation, and paclitaxel disrupts the interaction of STAT3 with tubulin. Paclitaxel signal transducer and activator of transcription 3 Homo sapiens
5 Paclitaxel also inhibits cytokine-induced STAT3 activation. Paclitaxel signal transducer and activator of transcription 3 Homo sapiens