Title : Serum levels of lamotrigine during delivery in mothers and their infants.

Pub. Date : 2010 Oct

PMID : 20692811






2 Functional Relationships(s)
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1 CONCLUSIONS: Our data from the large cohort showed the interindividual variability of umbilical cord/maternal serum concentration ratio in lamotrigine monotherapy caused probably by the different activity of the placental lamotrigine metabolizing enzymes UGT1A4 and 2B7 associated with genetic polymorphism. Lamotrigine UDP glucuronosyltransferase family 1 member A4 Homo sapiens
2 CONCLUSIONS: Our data from the large cohort showed the interindividual variability of umbilical cord/maternal serum concentration ratio in lamotrigine monotherapy caused probably by the different activity of the placental lamotrigine metabolizing enzymes UGT1A4 and 2B7 associated with genetic polymorphism. Lamotrigine UDP glucuronosyltransferase family 1 member A4 Homo sapiens