Title : Development of novel lipidated analogs of picroside as vaccine adjuvants: acylated analogs of picroside-II elicit strong Th1 and Th2 response to ovalbumin in mice.

Pub. Date : 2010 Dec 6

PMID : 20688035






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1 The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-gamma) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8). picroside II interferon gamma Mus musculus