Pub. Date : 2012 Feb
PMID : 20686816
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Unlike its cytotoxicity in p53-functional cell lines, Nutlin-1, the small-molecule inhibitor of murine double minute (MDM2), significantly enhanced the differentiation-inducing activity of all-trans retinoic acid (ATRA) in HL60 and NB4 cells (p53-nonfunctional) but not in U937 cells (p53 wild-type). | Tretinoin | tumor protein p53 | Homo sapiens |
2 | Unlike its cytotoxicity in p53-functional cell lines, Nutlin-1, the small-molecule inhibitor of murine double minute (MDM2), significantly enhanced the differentiation-inducing activity of all-trans retinoic acid (ATRA) in HL60 and NB4 cells (p53-nonfunctional) but not in U937 cells (p53 wild-type). | Tretinoin | tumor protein p53 | Homo sapiens |
3 | Moreover, we demonstrated that the synergistic differentiation-inducing activity of Nutlin-1 combined with ATRA appeared in a p53-independent manner. | Tretinoin | tumor protein p53 | Homo sapiens |