Title : Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.

Pub. Date : 2010 Aug 12

PMID : 20684610






1 Functional Relationships(s)
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1 A series of biphenylmethylene pyridines has been designed, synthesized, and tested as CYP17 and CYP11B1 inhibitors. biphenylmethylene pyridines cytochrome P450 family 11 subfamily B member 1 Homo sapiens