Title : A conserved region between the TPR and activation domains of p67phox participates in activation of the phagocyte NADPH oxidase.

Pub. Date : 2010 Oct 8

PMID : 20679349






1 Functional Relationships(s)
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1 Alanine substitution for Tyr-198, Leu-199, or Val-204 abrogates the ability of p67(phox) to support superoxide production by gp91(phox)-based oxidase as well as its related oxidases Nox1 and Nox3; the activation also involves other invariant residues such as Leu-193, Asp-197, and Gly-200. Superoxides NADPH oxidase 1 Homo sapiens