Title : Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential.

Pub. Date : 2010 Dec

PMID : 20678516






4 Functional Relationships(s)
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1 As glycine is an obligatory co-agonist at the NR1 subunit of the NMDA receptor, blockade of glycine uptake at the glycine transporter type-1 (GlyT1) can enhance low glutamatergic tone. Glycine solute carrier family 6 member 9 Homo sapiens
2 As glycine is an obligatory co-agonist at the NR1 subunit of the NMDA receptor, blockade of glycine uptake at the glycine transporter type-1 (GlyT1) can enhance low glutamatergic tone. Glycine solute carrier family 6 member 9 Homo sapiens
3 As glycine is an obligatory co-agonist at the NR1 subunit of the NMDA receptor, blockade of glycine uptake at the glycine transporter type-1 (GlyT1) can enhance low glutamatergic tone. Glycine solute carrier family 6 member 9 Homo sapiens
4 GlyT1 inhibitors blocked [(3)H]-glycine uptake in cells expressing the human transporter; other compounds had little or no activity. Glycine solute carrier family 6 member 9 Homo sapiens