Title : Determination of dermatan sulfate and chondroitin sulfate as related substances in heparin by capillary electrophoresis.

Pub. Date : 2010 Dec 15

PMID : 20674212






1 Functional Relationships(s)
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1 In particular, DeltaUA-->GalNAc-4S Na(2) and DeltaUA-->GalNAc-6S Na(2) were selected for quantitation of CS and DS because of their significant response and short migration time (less than 7min).The method was validated for linearity, accuracy, precision and it showed to be able in detecting selectively, DS and CS at impurity level (LOD 0.01%, w/w). Chondroitin Sulfates galactosamine (N-acetyl)-6-sulfatase Homo sapiens