Title : ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells.

Pub. Date : 2011 Feb

PMID : 20665703






1 Functional Relationships(s)
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1 The combination of ZD6474 with paclitaxel versus either agent alone also more potently down-regulated the antiapoptotic bcl-2 protein, up-regulated pro-apoptotic signaling events involving expression of bax, activation of caspase-3 and caspase-7 proteins, and induced poly(ADP-ribose) polymerase resulting in apoptosis. vandetanib caspase 3 Homo sapiens