Pub. Date : 2011 Feb
PMID : 20664610
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 2 | gamma-Aminobutyric acid (GABA) synthesis from glutamate is catalyzed by glutamate decarboxylase (GAD) of which two isoforms, GAD65 and GAD67, have been identified. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 3 | gamma-Aminobutyric acid (GABA) synthesis from glutamate is catalyzed by glutamate decarboxylase (GAD) of which two isoforms, GAD65 and GAD67, have been identified. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 4 | To specifically elucidate the significance of GAD65 for maintenance of the highly compartmentalized intracellular and intercellular GABA homeostasis, GAD65 knockout and corresponding wild-type mice were injected with [1-(13)C]glucose and the astrocyte-specific substrate [1,2-(13)C]acetate. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 5 | Synthesis of GABA from glutamine in the GABAergic synapses was further investigated in GAD65 knockout and wild-type mice using [1,2-(13)C]acetate and in some cases gamma-vinylGABA (GVG, Vigabatrin), an inhibitor of GABA degradation. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |
| 6 | Moreover, it was revealed that GAD65 is crucial for maintenance of biosynthesis of synaptic GABA particularly by direct synthesis from astrocytic glutamine via glutamate. | gamma-Aminobutyric Acid | glutamic acid decarboxylase 2 | Mus musculus |