Title : TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3beta pathway and activation of caspases.

Pub. Date : 2010 Jul 28

PMID : 20663232






1 Functional Relationships(s)
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1 Moreover, TRAIL inhibited P-gp efflux function via caspase-3-dependent degradation of P-gp as well as DNA-PKcs and subsequently sensitized MDR cells to MDR-related drugs such as vinblastine and doxorubicin. Doxorubicin TNF superfamily member 10 Homo sapiens