Pub. Date : 2010 Aug
PMID : 20662736
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Anthracycline (topoisomerase II inhibitors such as mitoxantrone and ellipticine) and camptothecin (topoisomerase I inhibitor) derivatives including topotecan induce DNA double strand breaks, which activate the p53 pathway through the ataxia telangiectasia mutated-checkpoint kinase 2 (ATM-CHK2) DNA damage response pathway. | ellipticine | tumor protein p53 | Homo sapiens |
2 | Although mitoxantrone, ellipticine, camptothecin, and topotecan all exhibited concentration-dependent disruption of the p53-hDM2 PPIB, they were much less potent than Nutlin-3. | ellipticine | tumor protein p53 | Homo sapiens |