Title : Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.

Pub. Date : 2010 Aug

PMID : 20662736






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Anthracycline (topoisomerase II inhibitors such as mitoxantrone and ellipticine) and camptothecin (topoisomerase I inhibitor) derivatives including topotecan induce DNA double strand breaks, which activate the p53 pathway through the ataxia telangiectasia mutated-checkpoint kinase 2 (ATM-CHK2) DNA damage response pathway. Anthracyclines ATM serine/threonine kinase Homo sapiens