Pub. Date : 2010 Aug
PMID : 20662736
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Anthracycline (topoisomerase II inhibitors such as mitoxantrone and ellipticine) and camptothecin (topoisomerase I inhibitor) derivatives including topotecan induce DNA double strand breaks, which activate the p53 pathway through the ataxia telangiectasia mutated-checkpoint kinase 2 (ATM-CHK2) DNA damage response pathway. | Anthracyclines | ATM serine/threonine kinase | Homo sapiens |