Pub. Date : 2010 Sep 10
PMID : 20661961
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A series of resorcylic acid macrolactones, analogues of the natural product radicicol has been prepared by chemical synthesis, and evaluated as inhibitors of heat shock protein 90 (Hsp90), an emerging attractive target for novel cancer therapeutic agents. | monorden | Hsp90 family chaperone HSP82 | Saccharomyces cerevisiae S288C |
| 2 | A series of resorcylic acid macrolactones, analogues of the natural product radicicol has been prepared by chemical synthesis, and evaluated as inhibitors of heat shock protein 90 (Hsp90), an emerging attractive target for novel cancer therapeutic agents. | monorden | Hsp90 family chaperone HSP82 | Saccharomyces cerevisiae S288C |
| 3 | Co-crystallization of one of the new macrolactones with the N-terminal domain of yeast Hsp90 confirms that it binds in a similar way to the natural product radicicol and to our previous synthetic analogues, but that the introduction of the additional hydroxymethyl substituent appears to result in an unexpected change in conformation of the macrocyclic ring. | monorden | Hsp90 family chaperone HSP82 | Saccharomyces cerevisiae S288C |