Title : HK-2 human renal proximal tubule cells as a model for G protein-coupled receptor kinase type 4-mediated dopamine 1 receptor uncoupling.

Pub. Date : 2010 Sep

PMID : 20660820






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 GRK4 small interfering RNA rescued the fenoldopam-mediated AC stimulation in the uncoupled cells, including HK-2. Fenoldopam G protein-coupled receptor kinase 4 Homo sapiens
2 The expected fenoldopam-mediated inhibition of sodium hydrogen exchanger type 3 was absent in HK-2 (n=6) and uncoupled RPTC cell lines (n=6) but was observed in the 2 normally coupled human RPTC cell lines (-25.41+/-4.7% and -27.36+/-2.70%; P<0.001; n=6), which express wild-type GRK4. Fenoldopam G protein-coupled receptor kinase 4 Homo sapiens