Title : Nuclear factor-κB/p65 responds to changes in the Notch signaling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the γ-secretase complex blocker DAPT.

Pub. Date : 2010 Sep

PMID : 20648656






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 However, in rats given an intraperitoneal injection of DAPT prior to LPS, Notch-1 labeling was augmented, but that of TNF-alpha and IL-1beta was reduced. dapt notch receptor 1 Rattus norvegicus
2 The results suggest that blocking of Notch-1 activation with DAPT would reduce the level of its downstream end product Hes-1 along with suppression of NF-kappaB/p65 translocation, resulting in suppressed production of proinflammatory cytokines. dapt notch receptor 1 Rattus norvegicus