Title : [Experimental study of the function and mechanism combining dihydroartemisinin and gemcitabine in treating pancreatic cancer].

Pub. Date : 2010 Apr 1

PMID : 20646665






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Western blot assay indicated that dihydroartemisinin downregulated expression of nuclear P65, and combined treatment not only downregulated the expression of Cyclin D1, Bcl-xL and Bcl-2 while upregulated Bax, thus reduced the Bcl-2/Bax ratio, but also increased the caspase-3 activation, all of which increased apoptosis in both BxPC-3 and Panc-1 cells. artenimol BCL2 associated X, apoptosis regulator Homo sapiens
2 Western blot assay indicated that dihydroartemisinin downregulated expression of nuclear P65, and combined treatment not only downregulated the expression of Cyclin D1, Bcl-xL and Bcl-2 while upregulated Bax, thus reduced the Bcl-2/Bax ratio, but also increased the caspase-3 activation, all of which increased apoptosis in both BxPC-3 and Panc-1 cells. artenimol BCL2 associated X, apoptosis regulator Homo sapiens