Title : Multiple species metabolism of PHA-568487, a selective alpha 7 nicotinic acetylcholine receptor agonist.

Pub. Date : 2010 Aug

PMID : 20642449






1 Functional Relationships(s)
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1 Quinuclidine oxidation was another pathway of importance, yielding an N-oxide (M12) which was also observed in all species.P450 2D6 and FMO1 catalyze the oxidation of the quinuclidine nitrogen. Nitrogen flavin containing dimethylaniline monoxygenase 1 Homo sapiens