Title : 99mTc-Hydrazinonicotinamide-galactosyl-chitosan

Pub. Date : 2004

PMID : 20641386






2 Functional Relationships(s)
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Protein Name
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1 Because ASGP-R recognizes galactose, (99m)Tc-diethylenetriamine pentaacetic acid-galactosyl-human serum albumin ((99m)Tc-GSA) (2, 3) and (99m)Tc-galactosyl-neoglycoalbumin ((99m)Tc-NGA) (4) are ASGP-R probes that accumulate specifically in the liver and are used for liver scintigraphy to determine liver mass and function. Galactose asialoglycoprotein receptor 1 Homo sapiens
2 (5) conjugated hydrazinonicotinamide (HYNIC) and galactose (via lactobionic acid) to deacetylate chitosan for radiolabeling with (99m)Tc to form (99m)Tc-HYNIC-galactosyl-chitosan ((99m)Tc-HGC) for imaging ASGP-R expression in the liver. Galactose asialoglycoprotein receptor 1 Homo sapiens