Title : Oleic acid synthesized in the periventricular zone promotes axonogenesis in the striatum during brain development.

Pub. Date : 2010 Sep

PMID : 20626566






6 Functional Relationships(s)
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1 In this study, we show that the rate-limiting enzyme in oleic acid synthesis, stearoyl-CoA desaturase (SCD-1), is located in the periventricular zone of the brain of newborn rats, simultaneously to an increase in the amount of free oleic acid in the forebrain. Oleic Acid stearoyl-CoA desaturase Rattus norvegicus
2 In this study, we show that the rate-limiting enzyme in oleic acid synthesis, stearoyl-CoA desaturase (SCD-1), is located in the periventricular zone of the brain of newborn rats, simultaneously to an increase in the amount of free oleic acid in the forebrain. Oleic Acid stearoyl-CoA desaturase Rattus norvegicus
3 In this study, we show that the rate-limiting enzyme in oleic acid synthesis, stearoyl-CoA desaturase (SCD-1), is located in the periventricular zone of the brain of newborn rats, simultaneously to an increase in the amount of free oleic acid in the forebrain. Oleic Acid stearoyl-CoA desaturase Rattus norvegicus
4 In this study, we show that the rate-limiting enzyme in oleic acid synthesis, stearoyl-CoA desaturase (SCD-1), is located in the periventricular zone of the brain of newborn rats, simultaneously to an increase in the amount of free oleic acid in the forebrain. Oleic Acid stearoyl-CoA desaturase Rattus norvegicus
5 In addition, the spatio-temporal presence of albumin - the signal that promotes oleic acid synthesis - and that of GAP-43 are correlated with that of SCD-1. Oleic Acid stearoyl-CoA desaturase Rattus norvegicus
6 In conclusion, our results suggest that albumin up-regulates axonogenesis in the striatum by increasing the amount of the neurotrophic factor oleic acid synthesized by SCD-1 in the periventricular zone of the newborn brain. Oleic Acid stearoyl-CoA desaturase Rattus norvegicus