Title : Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G₂/M checkpoint signaling.

Pub. Date : 2011 Jun

PMID : 20623183






1 Functional Relationships(s)
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1 We report that induction of ERbeta expression causes abrogation of the S-phase, and the Chk1/Cdc25C-mediated G2/M checkpoints after cisplatin and doxorubicin exposure in p53-defective breast cancer cells but not in p53 wild-type mammary cells. Cisplatin checkpoint kinase 1 Homo sapiens