Title : Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.

Pub. Date : 2010 Sep

PMID : 20606012






4 Functional Relationships(s)
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1 Here we demonstrate that AKT is a direct substrate of PTK6 and that AKT tyrosine residues 315 and 326 are phosphorylated by PTK6. Tyrosine thymoma viral proto-oncogene 1 Mus musculus
2 Here we demonstrate that AKT is a direct substrate of PTK6 and that AKT tyrosine residues 315 and 326 are phosphorylated by PTK6. Tyrosine thymoma viral proto-oncogene 1 Mus musculus
3 Association of PTK6 with AKT occurs through the SH3 domain of PTK6 and is enhanced through SH2 domain-mediated interactions following tyrosine phosphorylation of AKT. Tyrosine thymoma viral proto-oncogene 1 Mus musculus
4 Association of PTK6 with AKT occurs through the SH3 domain of PTK6 and is enhanced through SH2 domain-mediated interactions following tyrosine phosphorylation of AKT. Tyrosine thymoma viral proto-oncogene 1 Mus musculus