Title : Effects of ghrelin, GH-releasing peptide-6 (GHRP-6) and GHRH on GH, ACTH and cortisol release in hyperthyroidism before and after treatment.

Pub. Date : 2010 Dec

PMID : 20602173






3 Functional Relationships(s)
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1 In thyrotoxicosis before treatment ACTH response to ghrelin was two fold higher (107.4 +- 26.3) than those of controls (54.9 +- 10.3), although not significantly. Ghrelin proopiomelanocortin Homo sapiens
2 There was a trend to a decreased ACTH response to ghrelin after 3 months of euthyroidism (35.6 +- 5.3; P = 0.052), but after 6 months this decrease was non-significant (50.7 +- 14.0). Ghrelin proopiomelanocortin Homo sapiens
3 Our results suggest that the pathways of GH release after ghrelin/GHRP-6 and GHRH are similarly affected by thyroid hormone excess and hypothalamic mechanisms of ACTH release modulated by ghrelin/GHSs may be activated in this situation. Ghrelin proopiomelanocortin Homo sapiens