Pub. Date : 2010 Oct
PMID : 20600887
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When targeted via RGD to tumor-cell-surface and tumor neovasculature endothelial cell receptors, cationic liposomes could specifically deliver siRNAs to tumor cells and thus reverse drug resistance by down-regulation of P-gp, following administration of targeted liposomes containing DOX that inhibit formerly drug-resistant tumors. | Doxorubicin | phosphoglycolate phosphatase | Mus musculus |
| 2 | From the current results, the combination use of DOX and P-gp targeted siRNA showed significantly higher in vitro cytotoxicity in tumor cells than liposomal DOX alone. | Doxorubicin | phosphoglycolate phosphatase | Mus musculus |