Pub. Date : 2010 Aug 12
PMID : 20597485
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol. | dimethylenastron | kinesin family member 11 | Homo sapiens |
| 2 | Here, we report the crystal structures of the Eg5 motor domain complexed with enastron, dimethylenastron, and fluorastrol. | dimethylenastron | kinesin family member 11 | Homo sapiens |
| 3 | We also noticed preferential binding of the S-enantiomer of enastron and dimethylenastron to Eg5, while the R-enantiomer of fluorastrol binds preferentially to Eg5. | dimethylenastron | kinesin family member 11 | Homo sapiens |