Title : Inhibitors of p38 suppress cytokine production in rheumatoid arthritis synovial membranes: does variable inhibition of interleukin-6 production limit effectiveness in vivo?

Pub. Date : 2010 Nov

PMID : 20589681






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 RESULTS: SB-731445 and SB-203580 produced profound inhibition of spontaneous production of proinflammatory cytokines (TNFalpha and interleukin-1 [IL-1]) in both RA membrane cultures and LPS-stimulated primary human monocytes. SB 203580 tumor necrosis factor Homo sapiens