Title : Mechanisms of action of endothelin 1 in maturing rabbit airway smooth muscle.

Pub. Date : 1991 Jun

PMID : 2058688






1 Functional Relationships(s)
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1 Collectively, these findings demonstrate that ET-1 exerts a potent duality of action in rabbit TSM which varies significantly with maturation, wherein 1) age-dependent differences in airway relaxation are associated with changes in the evoked release of bronchodilatory prostaglandins and 2) maturational differences in airway contraction are associated with changes in Ins(1,4,5)P3 accumulation and extracellular Ca2+ mobilization, coupled to differences in PKC activation. Prostaglandins endothelin-1 Oryctolagus cuniculus