Title : Validation of a differential in situ perfusion method with mesenteric blood sampling in rats for intestinal drug interaction profiling.

Pub. Date : 2010 Jul

PMID : 20578213






1 Functional Relationships(s)
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1 This was demonstrated by identifying an interaction between amprenavir and ketoconazole (P-gp and CYP3A inhibitor) in five out of seven rats (permeability increase between 1.9- and 4.2-fold), despite high inter-individual differences in intrinsic permeability for amprenavir. amprenavir cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus