Title : Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity.

Pub. Date : 2010 Sep

PMID : 20570635






1 Functional Relationships(s)
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1 Trophoblasts transfected with ABCA1 or ABCG1 siRNA were more sensitive to toxic oxysterols substrates (25-hydroxycholesterol and 7-ketocholesterol) compared to mock-transfected cells, while prior treatment with T0901317 reduced oxysterol-mediated toxicity. 7-ketocholesterol ATP binding cassette subfamily G member 1 Homo sapiens