Pub. Date : 2010 Aug 1
PMID : 20559024
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By employing siRNA mediated knockdown of ZAK or administration of sorafenib and nilotinib, kinase inhibitors that have a high affinity for ZAK, we provide evidence that ZAK is required for doxorubicin-induced proinflammatory and apoptotic responses in HaCaT cells, a pseudo-normal keratinocyte cell line, but not in HeLa cells, a cancerous cell line. | Sorafenib | mitogen-activated protein kinase kinase kinase 20 | Homo sapiens |
| 2 | By employing siRNA mediated knockdown of ZAK or administration of sorafenib and nilotinib, kinase inhibitors that have a high affinity for ZAK, we provide evidence that ZAK is required for doxorubicin-induced proinflammatory and apoptotic responses in HaCaT cells, a pseudo-normal keratinocyte cell line, but not in HeLa cells, a cancerous cell line. | Sorafenib | mitogen-activated protein kinase kinase kinase 20 | Homo sapiens |
| 3 | Abrogation of these changes after exposure of cells to sorafenib and nilotinib suggests that these alterations occur following stimulation of ZAK. | Sorafenib | mitogen-activated protein kinase kinase kinase 20 | Homo sapiens |
| 4 | We suggest that ZAK inhibitors such as sorafenib or nilotinib may be effective when combined with doxorubicin to treat cancer patients. | Sorafenib | mitogen-activated protein kinase kinase kinase 20 | Homo sapiens |