Title : Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation.

Pub. Date : 2010 Sep

PMID : 20553682






2 Functional Relationships(s)
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1 At 2 h, ET-1 induced an increase in NADPH oxidase-driven O(2)(*-) production in rat isolated aortic rings, which was completely suppressed in PP2 (c-Src inhibitor)-pretreated rings, whereas PP3 (inactive analogue of PP2) was without effect. pp2 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
2 This effect was suppressed by coincubation with PP2 showing that this event is down-stream of c-Src activation. pp2 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus