Title : Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors.

Pub. Date : 2010 Jul 8

PMID : 20550118






1 Functional Relationships(s)
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1 Introduction of isopropylidene substituents onto the linker of biphenylmethylene 4-pyridines resulted in several strong CYP17 inhibitors, which were more potent and selective, regarding CYP 11B1, 11B2, 19 and 3A4, than the drug candidate abiraterone. biphenylmethylene 4-pyridines cytochrome P450 family 11 subfamily B member 1 Homo sapiens