Pub. Date : 2010 Jun
PMID : 20548120
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sialic acid biosynthesis occurs in the cytosol, where UDP-N-acetylglucosamine (GlcNAc) is sequentially converted to N-acetylmannosamine (ManNAc) 6-phosphate by UDP-GlcNAc-2-epimerase/ManNAc kinase enzymes, both of which are encoded by the GNE gene. | N-Acetylneuraminic Acid | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Mus musculus |
| 2 | Since the only existing mouse model of DMRV/hIBM (Gne(-/-)hGNED176VTg) exhibited decreased sialic acid levels in most organs, DMRV/hIBM is thought to be secondary to the metabolic defect in sialic acid production. | N-Acetylneuraminic Acid | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Mus musculus |
| 3 | Thus our results show that the oral therapy with NeuAc and ManNAc or their derivatives is safe and effective in preventing myopathic symptoms in Gne(-/-)hGNED176VTg mice, and could be considered as a guide for further therapeutic trials. | N-Acetylneuraminic Acid | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Mus musculus |