Title : Selective activation of human heat shock gene transcription by nitrosourea antitumor drugs mediated by isocyanate-induced damage and activation of heat shock transcription factor.

Pub. Date : 1991 Jun 1

PMID : 2052560






1 Functional Relationships(s)
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1 Treatment of cultured human tumor cells with the chloroethylnitrosourea antitumor drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) selectively induces transcription and protein synthesis of a subset of the human heat shock or stress-induced genes (HSP90 and HSP70) with little effect on other stress genes or on expression of the c-fos, c-myc, or beta-actin genes. 1-(2-chloroethyl)-1-nitrosourea Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens