Title : Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.

Pub. Date : 2010 Oct

PMID : 20522596






1 Functional Relationships(s)
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1 CONCLUSIONS: Our results demonstrate that the intramyocellular accumulation of ceramide correlates strongly with the development of insulin resistance, and suggests that inhibition of SPT1 is a potentially promising target for the treatment of insulin resistance. Ceramides serine palmitoyltransferase, long chain base subunit 1 Mus musculus