Title : Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activation.

Pub. Date : 2010 Aug

PMID : 20522591






1 Functional Relationships(s)
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1 Chronic treatment with the sGC activator HMR1766 improved NO sensitivity and endothelial function, reduced CYP2E1 expression and superoxide formation, enhanced 20-HETE levels, and reversed the contractile deficit observed in the diabetic rats that received placebo. Superoxides guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus