Title : Spinal matrix metalloproteinase-9 contributes to physical dependence on morphine in mice.

Pub. Date : 2010 Jun 2

PMID : 20519536






1 Functional Relationships(s)
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1 Morphine exposure and withdrawal increase phosphorylation of NR1 and NR2B receptors, ERK1/2, calmodulin-dependent kinase II, and cAMP response element binding proteins; and such phosphorylation is suppressed by either spinal inhibition or targeted mutation of MMP-9. Morphine mitogen-activated protein kinase 3 Mus musculus