Title : MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia.

Pub. Date : 2010 May 26

PMID : 20504344






1 Functional Relationships(s)
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1 Importantly, inhibition of miR-21 and miR-222 by anti-miRNA oligonucleotides induced a significant increase in caspase activity in fludarabine-treated p53-mutant MEG-01 cells, suggesting that miR-21 and miR-222 up-regulation may be involved in the establishment of fludarabine resistance. Oligonucleotides tumor protein p53 Homo sapiens