Title : Valine 375 and phenylalanine 109 confer affinity and specificity for pyruvate as donor substrate in acetohydroxy acid synthase isozyme II from Escherichia coli.

Pub. Date : 2010 Jun 29

PMID : 20504042






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Acetohydroxy acid synthase (AHAS) is a thiamin diphosphate-dependent enzyme that catalyzes the condensation of pyruvate with either another pyruvate molecule (product acetolactate) or 2-ketobutyrate (product acetohydroxybutyrate) as the first common step in the biosynthesis of branched-chain amino acids in plants, bacteria, algae, and fungi. Thiamine Pyrophosphate ilvB acetolactate synthase like Homo sapiens