Title : Accelerated wound healing by mTOR activation in genetically defined mouse models.

Pub. Date : 2010 May 13

PMID : 20498714






1 Functional Relationships(s)
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1 By the use of genetically defined approaches, including the epithelial-specific ablation of Pten and Tsc1, we show that mTOR activation can dramatically increase epithelial cell proliferation, migration, and cutaneous wound healing, while pharmacological inhibition of mTOR with rapamycin delays wound closure. Sirolimus phosphatase and tensin homolog Mus musculus